Systematic investigation of the aza-Cope reaction for fluorescence imaging of formaldehyde in vitro and in vivo
Open Access
- 5 October 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Science
- Vol. 12 (41) , 13857-13869
Abstract
Systematic investigation of various homoallylamines reveals N-p-methoxybenzyl homoallylamine as the optimal 2-aza-Cope reaction moiety for development of highly efficient formaldehyde fluorescent probes for in vitro and in vivo imaging.Keywords
Funding Information
- Shenzhen-Hong Kong Institute of Brain Science (2019SHIBS0004)
- National Natural Science Foundation of China (21602009)
- Science, Technology and Innovation Commission of Shenzhen Municipality (GXWD20201231165807007-20200814103057002)
This publication has 123 references indexed in Scilit:
- Lysine-Specific Demethylase 1 in Breast Cancer Cells Contributes to the Production of Endogenous Formaldehyde in the Metastatic Bone Cancer Pain Model of RatsPLOS ONE, 2013
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse FertilityMolecular Cell, 2013
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTONature Chemical Biology, 2011
- Tumor Tissue-Derived Formaldehyde and Acidic Microenvironment Synergistically Induce Bone Cancer PainPLOS ONE, 2010
- Formaldehyde in the Indoor EnvironmentChemical Reviews, 2010
- An Internal Reaction Chamber in Dimethylglycine Oxidase Provides Efficient Protection from Exposure to Toxic FormaldehydeJournal of Biological Chemistry, 2009
- Diabetes and semicarbazide-sensitive amine oxidase (SSAO) activity: A reviewLife Sciences, 2006
- Histone H3 Lysine 4 Demethylation Is a Target of Nonselective Antidepressive MedicationsChemistry & Biology, 2006
- Elevated semicarbazide-sensitive amine oxidase (SSAO) activity in lung with ischemia–reperfusion injury: Protective effect of ischemic preconditioning plus SSAO inhibitionLife Sciences, 2005
- How Constant Are Ritchie's “Constant Selectivity Relationships”? A General Reactivity Scale for n-, π-, and σ-NucleophilesJournal of the American Chemical Society, 2002