Rhodium(III)-Catalyzed Olefinic C–H Alkynylation of Acrylamides Using Tosyl-Imide as Directing Group
- 10 November 2014
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 16 (22) , 5956-5959
Abstract
The Rh(III)-catalyzed C–H alkynylation of acrylamide derivative is realized using a hypervalent alkynyl iodine reagent. The use of a weakly coordinating directing group proved to be of critical importance. This reaction displays broad functional group tolerance and high efficiency, which opens a new synthetic pathway to access functionalized 1,3-enyne skeletons.Keywords
Funding Information
- Ministry of Education of the People's Republic of China (ETRP 1002 111, MOE 2010-T2-2-067, MOE 2011-T2-1-013)
- Nanyang Technological University
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