Neural Network Functional Connectivity During and After an Episode of Delirium

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Abstract
Objective:Delirium is a common and potentially life-threatening clinical syndrome. The authors investigated resting-state functional connectivity in patients with delirium to elucidate possible neural mechanisms underlying this disorder. Method:Twenty-two patients underwent initial functional MRI at rest during an episode of delirium. Of these patients, 14 completed follow-up scans after the episode resolved. Twenty-two comparison subjects without delirium also underwent scanning. The authors assessed cortical functional connectivity using the seed region of the posterior cingulate cortex and functional connectivity strengths between a priori subcortical regions related to acetylcholine and dopamine on data from 20 initial and 13 follow-up scans. Results:Dorsolateral prefrontal cortex activity and posterior cingulate cortex activity were inversely correlated in comparison subjects but strongly correlated in patients during an episode of delirium as indicated by increased functional connectivity between th...

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