DFBP: a comprehensive database of food-derived bioactive peptides for peptidomics research

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Abstract
Food-derived bioactive peptides (FBPs) have demonstrated their significance in pharmaceuticals, diets and nutraceuticals, benefiting public health and global ecology. While significant efforts have been made to discover FBPs and to elucidate the underlying bioactivity mechanisms, there is lack of a systemic study of sequence–structure–activity relationship of FBPs in a large dataset. Here, we construct a database of food-derived bioactive peptides (DFBP), containing a total of 6276 peptide entries in 31 types from different sources. Further, we develop a series of analysis tools for function discovery/repurposing, traceability, multifunctional bioactive exploration and physiochemical property assessment of peptides. Finally, we apply this database and data-mining techniques to discover new FBPs as potential drugs for cardiovascular diseases. The DFBP serves as a useful platform for not only the fundamental understanding of sequence–structure–activity of FBPs but also the design, discovery, and repurposing of peptide-based drugs, vaccines, materials and food ingredients. DFBP service can be accessed freely via http://www.cqudfbp.net/. All data are incorporated into the article and its online supplementary material. Supplementary data are available at Bioinformatics online.
Funding Information
  • National Natural Science Foundation of China (32172196, 31771975, 31571782)
  • NSF (2107619)
  • Faculty Research Fellowship from the University of Akron
  • Natural Science Foundation of Chongqing Municipality (CSTC2019JCYJ-MSXMX0527)

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