Synthesis, in vitro hydroxyapatite forming ability, and cytocompatibility of strontium silicate powders

Authors:
Publisher website
Google Scholar
Abstract
Phase‐pure strontium silicate (SrSiO3) powders were synthesized by chemical precipitation method. In vitro bioactivity of the powders were evaluated by examining the hydroxyapatite forming ability on their surface soaking simulated body fluid for various periods. The results showed that SrSiO3 could induce hydroxy carbonate apatite formation after soaking for 7 days. Both L929 and rabbit bone marrow stromal cells (rMSCs) were used to test the in vitro cytocompatibility of SrSiO3. L929 culture experiment showed that the ionic product of SrSiO3 did not exhibit cytotoxicity except at high ion concentrations (Si 3.75 mM and Sr 0.12 mM). Moreover, at certain ion concentrations (Si 1.87–0.12 mM and Sr 0.12–3.75 × 10−3 mM), the ionic product of SrSiO3 stimulated the proliferation of rMSCs. All the results indicated that SrSiO3 might be used as a new bioactive material for bone regeneration applications. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010

This publication has 36 references indexed in Scilit: