Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features
Authors:
- Daiken SatakeDaiken Satake
- Manabu NatsumedaManabu Natsumeda
- Kaishi SatomiKaishi Satomi
- Mari TadaMari Tada
- Taro SatoTaro Sato
- Noritaka OkuboNoritaka Okubo
- Keita KawabeKeita Kawabe
- Haruhiko TakahashiHaruhiko Takahashi
- Yoshihiro TsukamotoYoshihiro Tsukamoto
- Masayasu OkadaMasayasu Okada
- Masakazu SanoMasakazu Sano
- Haruko IwabuchiHaruko Iwabuchi
Open Access
- 29 March 2024
- journal article
- case report
- Published by MDPI AG in Current Oncology
- Vol. 31 (4) , 1831-1838
Abstract
Molecular analysis of the growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, growing teratoma syndrome was suspected. A radical resection via the occipital transtentorial approach was performed, and histopathological examination revealed a teratoma with malignant features. Methylation classifier analysis confirmed the diagnosis of teratoma, and DMRT1 loss and 12p gain were identified by copy number variation analysis, potentially elucidating the cause of growth and malignant transformation of the teratoma. The patient remains in remission after intense chemoradiation treatment as a high-risk germ cell tumor.Keywords
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Funding Information
- Japan Society for the Promotion of Science (21KK0156, 20K09384)
- New Sustainable Growth (NSG) (21KK0156, 20K09384)
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