CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles
Authors:
- Isabel Martinez de la Peña Y ValenzuelaIVIsabel Martinez de la Peña Y Valenzuela
- Niels GaljartNGNiels Galjart
- Hans Rudolf BrennerHBHans Rudolf Brenner
- Eva MihailovskaEMEva Mihailovska
- Marianne RaithMRMarianne Raith
- Rocio G. ValenciaRVRocio G. Valencia
- Irmgard FischerIFIrmgard Fischer
Open Access
- 1 March 2015
- journal article
- Published by American Society for Cell Biology (ASCB) in Molecular Biology of the Cell
- Vol. 26 (5) , 938-951
Abstract
A novel mechanism is described for the agrin-mediated focal delivery of acetylcholine receptors (AChRs) to the postsynaptic membrane of the neuromuscular junction. Microtubule capture mediated by CLASP2 and its interaction partner, LL5β, and an intact subsynaptic actin cytoskeleton are both required for focal AChR transport to the synaptic membrane.Keywords
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