Greater Occipital Nerve Block is Ineffective in Chronic Tension Type Headache
Authors:
- 1 September 2005
- journal article
- clinical trial
- Published by SAGE Publications in Cephalalgia
- Vol. 25 (9) , 704-708
Abstract
Patients with primary headache syndromes often describe a pain distribution, that does not respect the trigeminal innervation of the head. In addition to pain in frontal areas, innervated by the first (ophthalmic) division of the trigeminal nerve, the pain often occurs in occipital parts of the head, innervated by the greater occipital nerve, a branch of the C2 spinal nerve root. Anatomical and neurophysiological studies in animals suggest a convergence of cervical and trigeminal input in the trigeminal nucleus caudalis. Modulation of this pathway has been discussed to be of potential benefit in headache disorders. We investigated in an open pilot study the effect of bilateral block of the greater occipital nerve with 50 mg prilocaine and 4 mg dexamethasone in patients with chronic tension type headache. From 15 patients, only one patient described a headache relief after initial exacerbation of headache for 2 days. Headache intensity was unchanged in 11 patients. In further three patients, the headache worsened in the first hours or days after injection. No serious adverse events were observed. One patient showed a bradycardia (36/min) after the first injection during palpation of the muscles of the neck. Three patients suffered pain on the injection site for a few days. Our results indicate that block of the greater occipital nerve is not effective in the treatment of chronic tension type headache. If at all, rather a ‘pro-nociceptive’ effect was observed.Keywords
This publication has 24 references indexed in Scilit:
- Increased responses in trigeminocervical nociceptive neurons to cervical input after stimulation of the dura materBrain, 2003
- Stimulation of the greater occipital nerve induces increased central excitability of dural afferent inputBrain, 2002
- Response properties of trigeminal brain stem neurons with input from dura mater encephali in the ratNeuroscience, 1999
- Chemical Stimulation of the Intracranial Dura Induces Enhanced Responses to Facial Stimulation in Brain Stem Trigeminal NeuronsJournal of Neurophysiology, 1998
- Stimulation of the greater occipital nerve increases metabolic activity in the trigeminal nucleus caudalis and cervical dorsal horn of the catPain, 1997
- Expression of c-Fos-like immunoreactivity in the caudal medulla and upper cervical spinal cord following stimulation of the superior sagittal sinus in the catBrain Research, 1993
- Headache and the greater occipital nerveClinical Neurology and Neurosurgery, 1992
- Central distribution of trigeminal and upper cervical primary afferents in the rat studied by anterograde transport of horseradish peroxidase conjugated to wheat germ agglutininJournal of Comparative Neurology, 1988
- A Mechanism to Account for Frontal Headache in Cases of Posterior-Fossa TumorsJournal of Neurosurgery, 1961
- OCCIPITAL NERVE TENDERNESS: A SIGN OF HEADACHESouthern Medical Journal, 1947