Cilia: Activation Coupled to Mechanical Stimulation by Calcium Influx

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Abstract
Ciliated epithelial cells in the oviduct of Necturus maculosus were stimulated mechanically by brief dimpling with a microstylus. This treatment produced a transient depolarization of the membrane, and a transient increase in the frequency of ciliary beating. The increase in frequency of ciliary beating was related to the concentration of extracellular calcium ion, decreasing with reduction in calcium. Addition of lanthanum was followed by a decrease in spontaneous ciliary activity and a hyperpolarization of the membrane. In the presence of lanthanum, the transient depolarization in response to mechanical stimulation had a shorter time course, and the concomitant increase in ciliary frequency was greatly reduced. It is concluded that calcium ions enter the cell as a result of mechanical stimulation of the membrane, and that calcium influx leads to an increase in the frequency of ciliary activity.

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