Carbon-13 nuclear magnetic resonance assignments and biosynthesis of aflatoxin B1 and sterigmatocystin

Authors:
  • KPKlaus G. R. Pachler
    Klaus G. R. Pachler
  • PSPieter S. Steyn
    Pieter S. Steyn
  • RVRobert Vleggaar
    Robert Vleggaar
  • PWPhilippus L. Wessels
    Philippus L. Wessels
  • DSDe Buys Scott
    De Buys Scott
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Abstract
The 13C n.m.r. spectra of two secondary fungal metabolites of related structure, aflatoxin B1 and sterigmatocystin, have been completely assigned. The distribution pattern of acetate units has been determined from 13C n.m.r. spectra of aflatoxin B1 derived from singly and doubly labelled [13C]acetate. These results and other published data on 13C-labelled sterigmatocystin agree with a biosynthetic scheme based on a C20 polyketide precursor.