Binding of anti–platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4
Open Access
- 9 October 2014
- journal article
- Published by American Society of Hematology in Blood
- Vol. 124 (15) , 2442-2449
Abstract
Key Points: Besides clustering, platelet factor 4/polyanion complexes require input of energy to become immunogenic. Minute differences in chain length determine the induction of antigenicity of PF4.Keywords
This publication has 35 references indexed in Scilit:
- Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight HeparinsScience, 2011
- Size-controlled formation of Cu nanoclusters in pulsed magnetron sputtering systemSurface and Coatings Technology, 2011
- Heparin modifies the immunogenicity of positively charged proteinsBlood, 2010
- Anti-cancer properties of low-molecular-weight heparin: Preclinical evidenceThrombosis and Haemostasis, 2009
- Triggers, targets and treatments for thrombosisNature, 2008
- Determinants of PF4/heparin immunogenicityBlood, 2007
- Relationship between the Growth Regime of Polyelectrolyte Multilayers and the Polyanion/Polycation Complexation EnthalpyThe Journal of Physical Chemistry B, 2006
- Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopeniaBlood, 2005
- Absence of cross-reactivity of SR90107A/ORG31540 pentasaccharide with antibodies to heparin-PF4 complexes developed in heparin-induced thrombocytopeniaBlood Coagulation & Fibrinolysis, 1997
- Heparin-Induced Thrombocytopenia in Patients Treated with Low-Molecular-Weight Heparin or Unfractionated HeparinNew England Journal of Medicine, 1995