Invasive Ductal Carcinoma of the Breast: Correlation Between Tumor Grade Determined by Ultrasound-Guided Core Biopsy and Surgical Pathology

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Abstract
OBJECTIVE. The purpose of this article is to evaluate the concordance between tumor grade found on ultrasound-guided core biopsies of invasive ductal carcinomas of the breast and subsequent excision specimens. MATERIALS AND METHODS. We retrospectively studied 300 consecutive invasive ductal carcinomas (274 women) that were biopsied under sonographic guidance, using 14-gauge core needles exclusively, and that were subsequently excised surgically. A minimum of four cores were taken per lesion. Core biopsy grades were compared with final surgical grades (reference standard). Tumor grade was assigned using the standard modified Scarff-Bloom-Richardson system. The agreement rate was expressed in percentages and in kappa statistics; the rates of overestimation and underestimation were also assessed. The correlation between tumor size (small, ≤ 0.5 cm; medium, 0.6–2.4 cm; and large, ≥ 2.5 cm) and agreement rate was also evaluated. RESULTS. The overall agreement between core biopsy and surgical pathology grade wa...

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