Canine teratogenesis with an estrogen antagonist
Authors:
- 1 April 1973
- journal article
- Published by Wiley in Teratology
- Vol. 7 (2) , 199-203
Abstract
A nonsteroidal estrogen antagonist, CI‐628, was administered orally to female beagle dogs on days 1–15 following mating. Dosages of 0.5, 1, 2, and 5 mg/kg effectively blocked pregnancy; six litters were whelped after 0.125 or 0.25 mg/kg in which various defects were present in pups of three litters.Keywords
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