Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection
- 4 March 2016
- journal article
- case report
- Published by Springer Nature in Journal of Gastroenterology
- Vol. 51 (11) , 1073-1080
Abstract
Interferon and nucleotide/nucleoside analogues are the main treatments for chronic hepatitis B. These drugs effectively reduce serum hepatitis B virus (HBV) DNA titers but fail to sufficiently reduce hepatitis B surface antigen (HBsAg) levels. Following the recent identification of sodium taurocholate cotransporting polypeptide as a receptor for HBV entry, inhibition of HBV entry has become an attractive therapeutic target for chronic hepatitis B treatment. We therefore evaluated the antiviral effects of antibody to HBsAg (anti-HBs) immunoglobulin (HBIG), which can inhibit HBV entry, by in an vivo study and a clinical trial.Keywords
This publication has 36 references indexed in Scilit:
- IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosomeJournal of Clinical Investigation, 2012
- Entecavir treatment for chronic hepatitis B: Adaptation is not needed for the majority of naïve patients with a partial virological responseHepatology, 2011
- Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA functionProceedings of the National Academy of Sciences, 2009
- HBsAg seroclearance in asymptomatic carriers of high endemic areasHepatology, 2007
- Infection of Human Hepatocyte Chimeric Mouse With Genetically Engineered Hepatitis B Virus *Hepatology, 2005
- Peginterferon Alfa-2a Alone, Lamivudine Alone, and the Two in Combination in Patients with HBeAg-Negative Chronic Hepatitis BNew England Journal of Medicine, 2004
- The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma.Genes & Development, 1987
- Modulation of the immunological response to hepatitis b virus by antibodiesHepatology, 1987
- Neutralization of Hepatitis B Virus Infectivity by a Murine Monoclonal Antibody: An Experimental Study in the ChimpanzeeJournal of Medical Virology, 1985
- INFUSION OF HEPATITIS-B ANTIBODY IN ANTIGEN-POSITIVE ACTIVE CHRONIC HEPATITISThe Lancet, 1973