Cross-coupling reaction of chloropyridazines and grignard reagents with nickel-phosphine complexes: Alkylation and arylation of pyridazines.

Authors:
  • AOAkio Ohsawa
    Akio Ohsawa
  • YAYoshihito Abe
    Yoshihito Abe
  • HIHiroshi Igeta
    Hiroshi Igeta
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Abstract
Alkyl- and arylpyridazines have been prepared by cross-coupling reaction between chloropyridazines and Grignard reagents in the presence of nickel-phosphine complexes (as catalysts). Hitherto unaccessible naphthyl- and thienylpyridazines have been obtained.