Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation
Authors:
- Mark GroudineMGMark Groudine
- Robert EisenmanRERobert Eisenman
- Harold WeintraubHWHarold Weintraub
- 1 July 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 292 (5821) , 311-317
Abstract
The transcriptionally active ev-3 and inactive ev-1 endogenous retrovirus loci in chick cells differ in that ev-3 is undermethylated, preferentially sensitive to DNase I digestion, and contains nuclease hypersensitive sites in each of its two long terminal repeats. Transient exposure of cells to 5-azacytidine, a cytosine analogue which cannot be methylated at the 5 position, results in the hypomethylation and transcriptional activation of ev-1, as well as the acquisition of at least one nuclease-hypersensitive site within the chromosomal domain of ev-1.Keywords
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