Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium
Open Access
- 29 October 2010
- journal article
- Published by Springer Nature in Respiratory Research
- Vol. 11 (1) , 150
Abstract
The production of gamma-amino butyric acid (GABA) is dependent on glutamate decarboxylases (GAD65 and GAD67), the enzymes that catalyze the decarboxylation of glutamate to GABA. Based on studies suggesting a role of the airway epithelial GABAergic system in asthma-related mucus overproduction, we hypothesized that cigarette smoking, another disorder associated with increased mucus production, may modulate GABAergic system-related gene expression levels in the airway epithelium.Keywords
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