Cu-Catalyzed Hydrodechlorination of Unactivated Alkyl Chlorides Using Diisobutylaluminum Hydride
Authors:
- 12 November 2024
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 26 (46) , 9943-9948
Abstract
A copper-catalyzed hydrodechlorination of primary, secondary, and tertiary alkyl chlorides using diisobutylaluminum hydride is reported. This catalytic system offers a broad substrate scope, high yields, and good functional group tolerance. Mechanistic investigations indicated that the reaction predominantly proceeds via a radical pathway, as supported by radical clock experiments. Importantly, this study provides a new approach for the selective hydrodechlorination of unactivated alkyl chlorides and expands the utility of Cu-hydride catalysis in sustainable chemical synthesis.Keywords
Funding Information
- Kwangwoon University
- National Research Foundation of Korea (NRF-2020R1A2C1005817)
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