Vitamin D or hormone D deficiency in autoimmune rheumatic diseases, including undifferentiated connective tissue disease
Open Access
- 1 January 2008
- journal article
- Published by Springer Nature in Arthritis Research & Therapy
- Vol. 10 (6) , 123
Abstract
Epidemiological evidence indicates a significant association between vitamin D deficiency and an increased incidence of autoimmune diseases. The presence of vitamin D receptors in the cells of the immune system and the fact that several of these cells produce the vitamin D hormone suggested that vitamin D could have immunoregulatory properties, and now potent immuno-modulatory activities on dendritic cells, Th1 and Th17 cells, as well as B cells have been confirmed. Patients with undifferentiated connective tissue disease also show vitamin D deficiency and, interestingly, patients who progress into connective tissue diseases have lower vitamin D levels than those who remain in the undifferentiated connective tissue disease stage.Keywords
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