Airways Remodelling in Asthma: No Doubt, No More?

Authors:
  • AVAntonio M. Vignola
    Antonio M. Vignola
  • PCPascal Chanez
    Pascal Chanez
  • ACAlison M. Campbell
    Alison M. Campbell
  • GBGiovanni Bonsignore
    Giovanni Bonsignore
  • FMFrançois-B. Michel
    François-B. Michel
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Abstract
Asthma is a chronic inflammatory disease of the airways invariably associated with healing. Remodelling of the airways can be demonstrated by the activation of airways macrophages, the release of growth factors and fibrogenic cytokines, the activation of fibroblasts and myofibroblast, elastolysis and elastosynthesis, collagen deposition, increased synthesis and release of extracellular matrix components, and an increased mass of smooth muscle and mucous glands. However, the control of remodelling is still poorly understood.