Pick the best of both glucose and lipid metabolism

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Abstract
Isthmin‐1 is an adipokine that has a potent glucose‐lowering effect by stimulating a common intracellular signaling pathway with insulin through a distinct receptor and has an inhibitory effect on lipogenesis in the liver, whereas insulin has the opposite effect. Isthmin‐1 is expected to have clinical benefits in the treatment of diabetes.
Funding Information
  • Japan Foundation for Applied Enzymology
  • Cell Science Research Foundation
  • Takeda Science Foundation
  • Naito Foundation
  • Uehara Memorial Foundation