Spontaneous heparin-induced thrombocytopenia syndrome: 2 new cases and a proposal for defining this disorder

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Abstract
Key Points: Two well-documented cases of a HIT-mimicking disorder without proximate heparin exposure (spontaneous HIT syndrome) are reported. The definition of spontaneous HIT syndrome should include strong serum-induced platelet activation at 0 IU/mL heparin (inhibited at 100 IU/mL).

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