High‐Dose Tamoxifen in Treatment of Brain Tumors: Interaction with Antiepileptic Drugs
Authors:
Abstract
Summary: The incidence of seizures related to primary brain tumors is 20–80%. High‐dose tamoxifen was recently reported as a novel treatment for patients with malignant gliomas who have failed standard therapies. Tamoxifen inhibits protein kinase C (PKC) in vitro and thus may regulate glioma cell growth by modulating intracellular signal transduction. We report a patient with a recurrent supratentorial pilocytic astrocytoma who had an untoward interaction between high‐dose tamoxifen therapy and phenytoin (PHT), drugs that share a common enzyme for metabolism, therefore emphasizing the need to monitor concomitant antiepileptic drug (AED) levels when high‐dose tamoxifen therapy is instituted.Keywords
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