The role of Parvovirus B19 infection in frequently ill children

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Abstract
Parvovirus B19 is a very common infection, especially in school-age children, with its rapid spread. In the present study, Parvovirus B19 infection was detected in frequently ill nursery children. The present study aimed to determine the seroprevalence value, to determine whether there is an active infection and to determine to what extent it affects the relevant immune system parameters, to determine whether the obtained data will contribute to the epidemiology of childhood Parvovirus B19 infections in our country and also, to determine whether it is a reason for children to become ill frequently. Parvovirus B19 DNA test results of 112 children aged 2–6 years who were grouped as frequently ill and infrequently ill and who went to nursery and kindergarten were examined quantitatively with the Real-Time PCR Method. Parvovirus B19 IgG and Parvovirus B19 IgM antibody presence was investigated with the ELISA Method. Flow Lymphocyte subgroups were analyzed with the Cytometry Method. Among the 112 patients who were included in the study, 105 (93.7%) Parvovirus B19 DNA results were negative and 7 (6.3%) were positive. Parvovirus B19 IgG test results were negative in 108 (96.4%) patients and positive in 4 (3.6%). When the Parvovirus B19 IgM results were evaluated, 109 (97.3%) were determined as negative and 3 (2.7%) positive. Natural Killer Cells (NK) from patients with positive Parvovirus B19 DNA, Parvovirus B19 IgG, and IgM were detected outside the normal limit value ranges in CD25, CD19, HLA DR, CD3, CD45RO, and CD8 values. No significant relationships were detected between frequent illness and Parvovirus B19 infection, the infection did not significantly affect the immunodeficiency parameters, and although it is already known that Parvovirus B19 infection peaks every 3–4 years, the study did not coincide with this period of Parvovirus B19 infection.

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