The Role of B and T Lymphocyte Attenuator in Respiratory System Diseases
Authors:
Open Access
- 7 June 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 12, 635623
Abstract
B and T lymphocyte attenuator (BTLA), an immunomodulatory molecule widely expressed on the surface of immune cells, can influence various signaling pathways and negatively regulate the activation and proliferation of immune cells by binding to its ligand herpes virus entry mediator (HVEM). BTLA plays an important role in immunoregulation and is involved in the pathogenesis of various respiratory diseases, including airway inflammation, asthma, infection, pneumonia, acute respiratory distress syndrome and lung cancer. In recent years, some studies have found that BTLA also has played a positive regulatory effect on immunity system in the occurrence and development of respiratory diseases. Since severe pulmonary infection is a risk factor for sepsis, this review also summarized the new findings on the role of BTLA in sepsis.Keywords
This publication has 67 references indexed in Scilit:
- B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patientsCritical Care, 2013
- BTLA Interaction with HVEM Expressed on CD8+ T Cells Promotes Survival and Memory Generation in Response to a Bacterial InfectionPLOS ONE, 2013
- CD8 T Cell Memory to a Viral Pathogen Requires Trans Cosignaling between HVEM and BTLAPLOS ONE, 2013
- HVEM signalling at mucosal barriers provides host defence against pathogenic bacteriaNature, 2012
- Active Immunotherapy Combined With Blockade of a Coinhibitory Pathway Achieves Regression of Large Tumor Masses in Cancer-prone MiceMolecular Therapy, 2011
- Regulation of inflammation, autoimmunity, and infection immunity by HVEM-BTLA signalingJournal of Leukocyte Biology, 2010
- T Cell Intrinsic Heterodimeric Complexes between HVEM and BTLA Determine Receptivity to the Surrounding MicroenvironmentThe Journal of Immunology, 2009
- B and T Lymphocyte Attenuator Tempers Early Infection ImmunityThe Journal of Immunology, 2009
- Unconventional ligand activation of herpesvirus entry mediator signals cell survivalProceedings of the National Academy of Sciences, 2009
- BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1Nature Immunology, 2003