Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic function

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Abstract
Significance: Because of the large number of cells, it is inevitable that the body of animals contains aberrant cells that may compromise the viability of the organism. Cell competition is a conserved mechanism responsible for removing those undesirable cells. Work in Drosophila and vertebrates has shown that cell competition also exerts a strong tumor-suppressing function, eliminating oncogenic cells that appear during the lifetime of the organism. Sometimes, however, oncogenic cells may overcome cell competition and develop invasive tumors. Studies of these situations may provide insights into the mechanisms by which oncogenic cells generate tumors in humans. We present new observations in Drosophila about the tumorigenic mutation polyhomeotic and how the mutant cells may evade the control of cell competition.
Funding Information
  • Ministerio de Ciencia e Innovación (PGC 2018-095151-B-100)
  • MINECO | Consejo Superior de Investigaciones Científicas (PIE 202020E255)

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