Carbonic anhydrase inhibitors: The X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors
Authors:
- Carlo PedoneCPCarlo Pedone
- Jochen AntelJAJochen Antel
- Harald WaldeckHWHarald Waldeck
- Andreas WitteAWAndreas Witte
- Michael WurlMWMichael Wurl
- Andrea ScozzafavaASAndrea Scozzafava
- Claudiu T. SupuranCSClaudiu T. Supuran
- Giuseppina De SimoneGiuseppina De Simone
- 1 April 2008
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 18 (8) , 2669-2674
Abstract
No abstract availableKeywords
This publication has 45 references indexed in Scilit:
- Carbonic anhydrase inhibitors: Cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamidesBioorganic & Medicinal Chemistry, 2007
- Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studiesBioorganic & Medicinal Chemistry Letters, 2005
- First Crystal Structures of Human Carbonic Anhydrase II in Complex with Dual Aromatase−Steroid Sulfatase Inhibitors,Biochemistry, 2005
- Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agentBiochemical Journal, 2005
- Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pHFEBS Letters, 2004
- Expression of Carbonic Anhydrase IX in Mouse TissuesJournal of Histochemistry & Cytochemistry, 2004
- Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme FamilyJournal of Biological Chemistry, 2004
- Review ArticleJournal of Enzyme Inhibition and Medicinal Chemistry, 2004
- [20] Processing of X-ray diffraction data collected in oscillation mode1997
- Positions of His‐64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitorsProtein Science, 1994