Bone marrow adipose tissue mass and dipeptidyl peptidase-4 link aging and metabolic health to biomarkers of bone turnover

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Abstract
Our findings highlight the central role of bone marrow adipose tissue in the relationship between bone health, age, and metabolism. Increased marrow adipocytes produce endocrine signals, such as dipeptidyl peptidase-4, which modulate these associations. We show that women and men have distinct associations between bone turnover, age, and bone marrow adipocytes.
Funding Information
  • Deutsches Zentrum für Diabetesforschung (01GI0925)
  • Deutsches Zentrum für Diabetesforschung (82DZD03D2G)
  • Deutsches Zentrum für Diabetesforschung (82DZD03D03)
  • Deutsche Forschungsgemeinschaft (249509554)
  • Deutsche Forschungsgemeinschaft (427826188)

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