Characterization of Modified RNA by Top‐Down Mass Spectrometry
Authors:
Open Access
- 8 October 2012
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 51 (45) , 11289-11292
Abstract
Characteristic mass differences between fragment ions from backbone cleavage of RNA by electron detachment (d, w) and fragment ions from collisionally activated dissociation (c, y) provide extensive sequence information (see picture). Structure analysis by this approach should be especially useful for the detailed characterization of synthetic or post‐transcriptionally modified RNA.Keywords
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