Evaluation of the use of UPLC-TOFMS with simultaneous [14C]-radioflow detection for drug metabolite profiling: Application to propranolol metabolites in rat urine
Authors:
- R.L. SisonRSR.L. Sison
- A.S.J. KenyonAKA.S.J. Kenyon
- J.A. Clarkson-JonesJCJ.A. Clarkson-Jones
- I.D. WilsonIWI.D. Wilson
- 1 September 2008
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical and Biomedical Analysis
- Vol. 48 (1) , 151-157
Abstract
No abstract availableKeywords
This publication has 22 references indexed in Scilit:
- The metabolomics of (±)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenasesBiochemical Pharmacology, 2007
- Ultra‐performance liquid chromatography/time‐of‐flight mass spectrometry based metabolomics of raw and steamed Panax notoginsengRapid Communications in Mass Spectrometry, 2007
- Novel Application of Reversed-Phase UPLC-oaTOF-MS for Lipid Analysis in Complex Biological Mixtures: A New Tool for LipidomicsJournal of Proteome Research, 2006
- The detection of phenotypic differences in the metabolic plasma profile of three strains of Zucker rats at 20 weeks of age using ultra‐performance liquid chromatography/orthogonal acceleration time‐of‐flight mass spectrometryRapid Communications in Mass Spectrometry, 2006
- Metabonomics Study of Intestinal Fistulas Based on Ultraperformance Liquid Chromatography Coupled with Q-TOF Mass Spectrometry (UPLC/Q-TOF MS)Journal of Proteome Research, 2006
- Advancing LC Performance with Smaller Particles and Higher PressureAnalytical Chemistry, 2005
- A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude miceThe Analyst, 2005
- High Resolution “Ultra Performance” Liquid Chromatography Coupled to oa-TOF Mass Spectrometry as a Tool for Differential Metabolic Pathway Profiling in Functional Genomic StudiesJournal of Proteome Research, 2005
- Metabolite profiling study of propranolol in rat using LC/MS/MS analysisBiomedical Chromatography, 1999
- Arene Oxides: A New Aspect of Drug MetabolismScience, 1974