In this chapter, the authors review the literatures on leader–member exchange (LMX) and on constructs related to job stress (job stressors, well-being, work–family interface), and describe how LMX is associated with these job-stress constructs. They present an integrative framework that specifies bidirectional relationships between LMX and job-stress constructs and that proposes LMX as a moderator in the relationships between the job-stress constructs. They summarize empirical research on the relationships of LMX with job stressors, well-being, and work–family variables and conclude by suggesting directions for practice and future research emphasizing the need for more methodologically sound studies.