Preparation of Vinylphosphonates from Ketones Promoted by Tf2O
- 21 February 2023
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 88 (5) , 2898-2907
Abstract
: An efficient triflic anhydride promoted phosphorylation of ketone was disclosed, and vinylphosphorus compounds were prepared under solvent- and metal-free conditions. Both aryl and alkyl ketones could perform smoothly to give vinyl phosphonates in high to excellent yields. In addition, the reaction was easy to carry out and easy to scale up. Mechanistic studies suggested that this transformation might involve nucleophilic vinylic substitution or a nucleophilic addition-elimination mechanism.Keywords
Funding Information
- Liaocheng University (318051437)
- National Natural Science Foundation of China (21502084, 21901097)
- Introduction and Cultivation Program for Young Innovative Talents in Shandong Provincial Colleges and Universities
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