Erk 1,2 phosphorylates p27 Kip1 : Functional evidence for a role in high glucose-induced hypertrophy of mesangial cells
Authors:
- 10 July 2003
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 46 (8) , 1090-1099
Abstract
Mesangial cell hypertrophy is one of the earliest morphological abnormalities of diabetic nephropathy. We have previously shown that high glucose induces p27Kip1 by a post-transcriptional mechanism and that mesangial cell hypertrophy depends on G1-phase arrest mediated by this CDK-inhibitor. However, it remains poorly understood how high glucose stimulates p27Kip1 expression in mesangial cells.Keywords
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