Application of the Mannich reaction in the structural modification of natural products
Open Access
- 14 July 2023
- journal article
- review article
- Published by Taylor & Francis in Journal of Enzyme Inhibition and Medicinal Chemistry
- Vol. 38 (1) , 2235095
Abstract
The Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve the activity, hydrophilicity, and medicinal properties of compounds; therefore, the Mannich reaction is widely used for the structural modification of natural products. In this paper, the application of the Mannich reaction to the structural modification of natural products is reviewed, providing a method for the structural modification of natural products.Keywords
Funding Information
- National Natural Science Foundation of China (81960626, 82060628, 82204310)
- Key Projects of Jilin Province Science and Technology Development Plan (20200404130YY)
- Jilin Provincial Scientific and Technological Development Program (YDZJ202301ZYTS440, YDZJ202301ZYTS143)
- Education Department Project of Jilin (JJKH20220546KJ, JJKH20220563KJ)
This publication has 106 references indexed in Scilit:
- Synthesis and biological evaluation of 1, 3-dihydroxyxanthone mannich base derivatives as anticholinesterase agentsBMC Chemistry, 2013
- Protective effect of esculetin on hyperglycemia-mediated oxidative damage in the hepatic and renal tissues of experimental diabetic ratsBiochimie, 2013
- Nitrogen-Containing Apigenin Analogs: Preparation and Biological ActivityMolecules, 2012
- Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic ratsMetabolism, 2011
- Protective Effects of Luteolin on Diabetic Nephropathy in STZ‐Induced Diabetic RatsEvidence-Based Complementary and Alternative Medicine, 2011
- Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic DisordersMolecules, 2010
- Vitamin B6: A Long Known Compound of Surprising ComplexityMolecules, 2009
- The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and ToxicityJournal of Biological Chemistry, 2008
- The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitroLife Sciences, 2007
- Therapeutic potential of resveratrol: the in vivo evidenceNature Reviews Drug Discovery, 2006