A More Comprehensive and Highly Practical Solution to Enantioselective Aldehyde Crotylation
- 12 April 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 133 (17) , 6517-6520
Abstract
The enantioselective crotylation of aldehydes with 1,2-diaminochlorocrotylsilane reagents is effectively catalyzed by Sc(OTf)3. The one significant limitation on the utility of these reagents − substrate scope − has thus been addressed. The net result is the most comprehensive and highly practical method for enantioselective aldehyde crotylation yet advanced.Keywords
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