Toward the Total Synthesis ofDisorazole A1: Asymmetric Synthesis of the MaskedNorthern Half

Authors:
  • IHIngo V. Hartung
    Ingo V. Hartung
  • UEUlrike Eggert
    Ulrike Eggert
  • LHLars Ole Haustedt
    Lars Ole Haustedt
  • BNBarbara Niess
    Barbara Niess
  • PSPeter M. Schäfer
    Peter M. Schäfer
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Abstract
The stereoselective synthesis of the masked northern half ofthe antimitotic natural product disorazole A1 is describedinvol­ving as key step a Z-selectiveWittig olefination of a C1-C11 epoxy aldehyde with a C12-C19phosphonium iodide.