The insulin-like growth factor system as a therapeutic target in colorectal cancer
Authors:
Open Access
- 1 March 2002
- journal article
- review article
- Published by Elsevier in Annals of Oncology
- Vol. 13 (3) , 349-356
Abstract
The purpose of this review is to examine recent evidence that investigates the role of the insulin-like growth factor (IGF) system in colorectal cancer. We concentrate on the evidence that makes the case for the investigation of strategies that might be used to disrupt the IGF system in prevention and treatment. Even though the weight of evidence suggests that components of the IGF system may be appropriate targets, there are a lack of studies that make a systematic characterisation of all the system components in human colorectal cancer. It is anticipated that this information, and the new therapeutic molecules which follow, will impact on the prevention and treatment of patients with this disease.Keywords
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