Mapping the Gene for Hereditary Cutaneous Malignant Melanoma–Dysplastic Nevus to Chromosome Lp
Authors:
- Nicholas C. DracopoliNDNicholas C. Dracopoli
- Margaret A. TuckerMTMargaret A. Tucker
- Wallace H. ClarkWCWallace H. Clark
- Mary C. FraserMFMary C. Fraser
- Ben Z. StangerBSBen Z. Stanger
- Philip GreenPGPhilip Green
- Helen Donis-KellerHDHelen Donis-Keller
- David E. HousmanDHDavid E. Housman
- Mark H. GreeneMGMark H. Greene
- 25 May 1989
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 320 (21) , 1367-1372
Abstract
We used molecular genetic techniques and multipoint linkage analyses to locate the gene responsible for cutaneous malignant melanoma-dysplastic nevus. We evaluated 99 relatives and 26 spouses in six families with a predisposition to melanoma. Thirty-four family members had cutaneous malignant melanoma, and 31 of these 34 also had histologically confirmed dysplastic nevi. Twenty-four family members had dysplastic nevi alone.Keywords
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