Penetration of Topically Administered 0.5-Percent Caspofungin Eye Drops into Human Aqueous Humor

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Abstract
Ten participants attending elective anterior segment eye surgery received 0.5% caspofungin eye drops either 1 drop hourly for 4 h or 1 drop an hour before surgery. The eye drops were generally well tolerated. In the absence of inflammation or corneal abrasion, topical caspofungin does not achieve clinically relevant concentrations.

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