IFITM3 protects the heart during influenza virus infection

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Abstract
Significance: We discovered that IFITM3 prevents efficient dissemination and replication of influenza virus in heart tissue, thereby limiting cardiac fibrosis and electrical dysfunction during infection. Since IFITM3 polymorphisms are among the only human genetic factors that have been reproducibly associated with hospitalization and mortality during influenza virus infection, our findings are relevant to the serious threat of influenza virus infection to human health. Furthermore, IFITM3 KO mice provide one of the first models for studying cardiac complications of influenza.
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  • HHS | NIH | National Institute of Allergy and Infectious Diseases (AI0130110)
  • HHS | NIH | National Institute of Allergy and Infectious Diseases (AI146690)

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