One-Pot, Three-Component Synthesis of 5-Sulfenyl-2-iminothiazolines by Cross-Dehydrogenative C–S Coupling Using I2/DMSO in Open Air
- 10 May 2019
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 84 (11) , 7265-7278
Abstract
A one-pot three component transition metal-free regioselective sulfenylation of 2-iminothiazoline through cross dehydrogenative coupling (CDC) strategy via sp2 C-H functionalization has been developed employing iodine as catalyst and DMSO as an oxidant. Utility of this sulfenylation technique was well depicted through participation of various aryl and heterocyclic thiols. Significant features of this C-H functionalization strategy include metal-free open air reaction conditions which offer mild and efficient method for sulfenylation to achieve diversely substituted 5-sulfenyl-2-iminothiazoline derivatives.Keywords
Funding Information
- University Grants Commission
- Department of Science and Technology, Ministry of Science and Technology
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