Calcium-RasGRP2-Rap1 signaling mediates CD38-induced migration of chronic lymphocytic leukemia cells
Open Access
- 3 July 2018
- journal article
- research article
- Published by American Society of Hematology in Blood Advances
- Vol. 2 (13) , 1551-1561
Abstract
Key Points: Basal intracellular Ca2+ levels and migration increase with higher CD38 expression in CLL cells. Rap1 and the Rap1 guanine-nucleotide exchange factor RasGRP2 are required for CLL migration and regulated by CD38 levels.Keywords
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