Myelin Basic Protein as an Encephalitogen in Encephalomyelitis and Polyneuritis Following Rabies Vaccination
Authors:
- Thiravat HemachudhaTHThiravat Hemachudha
- Diane E. GriffinDGDiane E. Griffin
- J. Joseph GiffelsJGJ. Joseph Giffels
- Richard T. JohnsonRJRichard T. Johnson
- Ann B. MoserAMAnn B. Moser
- Praphan PhanuphakPPPraphan Phanuphak
- 12 February 1987
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 316 (7) , 369-374
Abstract
Encephalitis and polyneuritis occurring after rabies vaccination are believed to be immunologically mediated. We studied antibody responses to neural antigens in 36 patients with major neurologic complications, 25 with minor complications, and 39 with no complications after immunization with a brain-derived, Semple rabies vaccine. Patients with major complications had significantly elevated levels of antibody to brain white matter as compared with the other groups (P1b and GT1b. No antibodies to myelin-associated glycoprotein were detected in any of the samples.Keywords
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