Production of Lymphotoxin, a Bone-Resorbing Cytokine, by Cultured Human Myeloma Cells
Authors:
- I. Ross GarrettIGI. Ross Garrett
- Brian G.M. DurieBDBrian G.M. Durie
- Glenn E. NedwinGNGlenn E. Nedwin
- Alison GillespieAGAlison Gillespie
- Timothy BringmanTBTimothy Bringman
- Massimo SabatiniMSMassimo Sabatini
- Donald R. BertoliniDBDonald R. Bertolini
- Gregory R. MundyGMGregory R. Mundy
- 27 August 1987
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 317 (9) , 526-532
Abstract
Myeloma cells destroy bone by producing an osteoclast-stimulating factor that has chemical and biological characteristics similar to the bone-resorbing activity present in the supernatants of activated leukocyte cultures. Recently, a number of bone-resorbing leukocyte cytokines have been identified, including interleukin-1, lymphotoxin, and tumor necrosis factor. We have examined the products of human myeloma cells for the presence of these bone-resorbing cytokines.Keywords
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