Steroid-Responsive Chronic Cerebellitis With Positive Glutamate Receptor δ2 Antibody
- 13 December 2007
- journal article
- case report
- Published by SAGE Publications in Journal of Child Neurology
- Vol. 23 (2) , 228-230
Abstract
We report the clinical course of a 4-year-old girl with chronic cerebellitis (onset 2 days after diphtheria-pertussis-tetanus vaccination at 1 year and 7 months old) associated with anti-glutamate receptor δ2 antibody, who improved dramatically with steroid therapy (methylprednisolone pulse therapy plus oral prednisolone). Recently, it has been reported that the anti-glutamate receptor δ2 selectively expressed at the post-synaptic site of parallel fiber—Purkinje cell synapses has an important role in cerebellar function in the developing brain. The present case suggests that anti-glutamate receptor δ2 antibody plays a primary role in an immune-mediated process causing chronic cerebellar symptoms, and the lesion site seems to be localized to the parallel fiber—Purkinje cell synapse. Because the cerebellum is strongly involved in language acquisition as well as motor development, treatment must facilitate time for language learning while reducing the side effects of the corticosteroid therapy.Keywords
This publication has 6 references indexed in Scilit:
- New role of δ2-glutamate receptors in AMPA receptor trafficking and cerebellar functionNature Neuroscience, 2003
- Classical eyeblink conditioning in glutamate receptor subunit δ2 mutant mice is impaired in the delay paradigm but not in the trace paradigmEuropean Journal of Neuroscience, 2001
- Mechanisms of motor learning in the cerebellum11Published on the World Wide Web on 24 November 2000.Brain Research, 2000
- Impaired Parallel Fiber→Purkinje Cell Synapse Stabilization during Cerebellar Development of Mutant Mice Lacking the Glutamate Receptor δ2 SubunitThe Journal of Neuroscience, 1997
- Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluRδ2 mutant miceCell, 1995
- Selective Expression of the Glutamate Receptor Channel δ2 Subunit in Cerebellar Purkinje CellsBiochemical and Biophysical Research Communications, 1993