Total Synthesis of Diterpenoid Quinone Methide Tumor Inhibitor, (+)-Taxodione
Authors:
- 16 January 2024
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 89 (3) , 1823-1835
Abstract
An asymmetric polyene cyclization (92% ee) strategy has been successfully applied for the first asymmetric total synthesis of oxidized abietane, anticancer agent, taxodione (1) sharing a trans-decalin system. Additionally, the total syntheses of pomiferin B (2) and gaultheric acid (3) (a nor-abietane) were achieved utilizing this unified approach.Keywords
Funding Information
- Anusandhan National Research Foundation (STR/2020/000061, CRG/2019/000113, SCP/2022/000486)
- Ministry of Education, India (2023/0753)
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