Clinical features in adults with acquired cutis laxa: a retrospective review

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Abstract
Dear Editor, Acquired cutis laxa (ACL) is a rare dermatological condition with numerous proposed aetiologies including medications, malignancy, infection, enzyme disorders, autoimmunity and renal disease, and although the pathogenesis of inherited CL is somewhat understood, little is known about ACL.1 ACL is presumed to be a sequela of environmental exposures leading to elastic fibre destruction.2 ACL typically presents in adulthood, and diagnosis is based on history and clinical examination followed by histopathology revealing reduction in elastic fibres or elastic fibre fragmentation.2,3 Patients have localized or generalized wrinkled skin, and disease is either insidious or associated with preceding inflammation.1,2 This study aimed to better understand potential presentations and triggers of ACL. Following approval by the Institutional Review Board at Mass General Brigham (MGB), patients diagnosed with CL from January 1989 to April 2021 at MGB hospitals were identified using the Research Patient Data Registry. Inherited CL was excluded. Data were then extracted from medical records.
Funding Information
  • National Institutes of Health (R01 AR071491)
  • Yale Center for Mendelian Genomics (U54 HG006504/HG/NHGRI)

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