Activation of B lymphocytes by locally concentrated concanavalin A
Authors:
- J. AnderssonJAJ. Andersson
- G. M. EdelmanGEG. M. Edelman
- O. SjöbergOSO. Sjöberg
- 1 June 1972
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 2 (3) , 233-235
Abstract
B lymphocytes are not stimulated by soluble concanavalin A (Con A). However, Con A cross‐linked at the bottom of tissue culture petri dishes could activate DNA synthesis in B cells. Addition of free Con A to such cultures inhibited the proliferative response to insoluble Con A. T lymphocytes were not activated by locally concentrated Con A, although they responded to soluble Con A. In the presence of both soluble and cross‐linked Con A there was a shift in the dose response curve to soluble Con A, the magnitude of which varied with the concentration of cross‐linked Con A.Keywords
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