A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction
Open Access
- 22 January 2019
- journal article
- research article
- Published by Springer Nature in Oncogene
- Vol. 38 (20) , 3824-3842
Abstract
No abstract availableKeywords
Funding Information
- This research was supported by NHMRC, Leukaemia Foundation, Anthony Rothe Memorial Trust, NSW Cancer Council, Cancer Institute NSW, Tenix Foundation and ISG Foundation.
This publication has 56 references indexed in Scilit:
- A Rationally Optimized Nanoparticle System for the Delivery of RNA Interference Therapeutics into Pancreatic Tumors in VivoBiomacromolecules, 2016
- Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid LeukemiaCancer Cell, 2015
- ER stress-induced cell death mechanismsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013
- BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem CellsCell Stem Cell, 2013
- Effect of sulfonamides as carbonic anhydrase VA and VB inhibitors on mitochondrial metabolic energy conversionBioorganic & Medicinal Chemistry, 2013
- Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drugJournal of Bioenergetics and Biomembranes, 2012
- Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid LeukemiaCancer Cell, 2011
- Hallmarks of Cancer: The Next GenerationCell, 2011
- HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumptionCell Metabolism, 2006
- How might you compare mitochondria from different tissues and different species?Journal of Comparative Physiology B, 2006