A study of 59 cases of acute coccidioidomycosis admitted to the 4510 USAF Hospital, Luke AFB, Arizona, between January 1, 1967 and December 31, 1968 was conducted to define the roentgen manifestations of acute coccidioidomycosis. A wide spectrum of roentgen abnormalities was experienced. The most common manifestation was found to be pneumonitis. Pleural effusion and hilar and mediastinal enlargement were the next most frequent modes of presentation. Combinations of roentgen abnormalities such as infiltrate and lymphadenopathy or infiltrate and effusion were common. A high incidence of skin lesions, comprised of toxic erythema, erythema nodosum, and erythema multiforme, were found in patients with acute disease.Recognizing the large transient military population and annual tourist exposure in the endemic southwestern United States, awareness of the varied forms of presentation of coccidioidomycosis seems increasingly appropriate for radiologists in non-endemic areas.Although the roentgen findings of this d...